he nearly runs over a dog with his car. The dog yells "bonehead" and disappears. From then on, his childhood ability is back: To communicate with animals. Unfortunately, the word of Dolittle's ability is spreading quickly. Soon, many animals from rat to horse flock to his place to get medical advice. But his colleagues suspect he's going mad, and as the clinic Dolittle used to work for is about to being taken over for a huge amount of money, many decisions have to be made. Believe him? Put him into a mental institution? Sell the clinic? But also his family is close to breaking apart. Until a circus tiger falls seriously ill.

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earn that Professor Plum works in D.C., where everyone else lives. Colonel Mustard is a client of Miss Scarlet, who is the ex-employer of Yvette, the maid, who had an affair with the husband of Mrs. White, etc. When Mr. Boddy, who is blackmailing each guest, gives the guests each a weapon, he tells them they should kill Wadsworth, the butler, to avoid being exposed. With Mrs. Peacock's craziness, and Mr. Green's clumsiness, the whole group finds themselves tangled in a web of murder, lies, and hilarity.

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